کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7868380 1509162 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Injectability, microstructure and release properties of sodium fusidate-loaded apatitic cement as a local drug-delivery system
ترجمه فارسی عنوان
خواص تزریقی، ریزساختار و انتشار سیتوپاتی آپاتیت سدیم فوزیته به عنوان یک سیستم تحویل دارویی محلی
کلمات کلیدی
سیمان آفت کش، انعطاف پذیری، آنتی بیوتیک، انتشار مواد مخدر، سیستم تحویل،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی
The introduction of an antibiotic, sodium fusidate (SF), into the liquid phase of calcium carbonate-calcium phosphate (CaCO3-CaP) bone cement was evaluated, considering the effect of the liquid to powder ratio (L/P) on the composition and microstructure of the set cement and the injectability of the paste. In all cases, we obtained set cements composed mainly of biomimetic carbonated apatite analogous to bone mineral. With this study, we evi-denced a synergistic effect of the L/P ratio and SF presence on the injectability (i.e., the filter-pressing pheno-menon was suppressed) and the setting time of the SF-loaded cement paste compared to reference cement (without SF). In addition, the in vitro study of SF release, according to the European Pharmacopoeia recommendations, showed that, regardless of the L/P ratio, the cement allowed a sustained release of the antibiotic over 1 month in sodium chloride isotonic solution at 37 °C and pH 7.4; this release is discussed considering the microstructure characteristics of SF-loaded cements (i.e., porosity, pore-size distribution) before and after the release test. Finally, modelling antibiotic release kinetics with several models indicated that the SF release was controlled by a diffusion mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 59, 1 February 2016, Pages 177-184
نویسندگان
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