کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7868871 1509163 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fluorescent molecularly imprinted polymers based on 1,8-naphthalimide derivatives for efficiently recognition of cholic acid
ترجمه فارسی عنوان
پلیمرهای مشتق شده از لحاظ فلورسانس بر اساس مشتقات 1،8-نفتالیمید برای شناسایی موثر اسید های کولیک
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی
Fluorescent molecularly imprinted polymers (MIPs) have attracted increasing attentions in recent years due to their high selectivity and sensitivity for target molecules. In this study, two cholic acid imprinted fluorescent polymers, i.e., MIP1 and MIP2, were prepared using 4-dimethylamino-N-allylnaphthalimide (F1) and 4-piperazinyl-N-allylnaphthalimide (F2) as the fluorescent functional monomers, respectively. The fluorescence intensity of MIP1 decreased linearly with the increase of the template concentration in the range of 1.50-120.0 μM, while the fluorescence intensity of MIP2 increased linearly with the increase of the template concentration in the range of 0.40-110.0 μM. The detection limits of MIP1 and MIP2 for cholic acid were 0.42 and 0.083 μM, respectively. The mechanisms of the fluorescence responsive of the imprinted polymers were discussed. The results of fluorescence measurement and binding experiments demonstrated that both imprinted polymers have high recognition abilities and binding affinities for the template. The imprinted polymers have been successfully applied to the determination of cholic acid in human serums. The present study indicated that 1,8-naphthalimide can be used as a modular building block for design and construction of various fluorogenic molecularly imprinted materials for practical sensing and separation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 58, 1 January 2016, Pages 558-567
نویسندگان
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