کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7869780 | 1509175 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dithranol-loaded lipid-core nanocapsules improve the photostability and reduce the in vitro irritation potential of this drug
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dithranol-loaded lipid-core nanocapsules improve the photostability and reduce the in vitro irritation potential of this drug Dithranol-loaded lipid-core nanocapsules improve the photostability and reduce the in vitro irritation potential of this drug](/preview/png/7869780.png)
چکیده انگلیسی
EDTA (0.05%) or ascorbic acid (0.02%) was used as antioxidants. After preparation, dithranol-loaded lipid-core nanocapsules showed satisfactory characteristics: drug content close to the theoretical concentration, encapsulation efficiency of about 100%, nanometric mean size (230-250Â nm), polydispersity index below 0.25, negative zeta potential, and pH values from 4.3 to 5.6. In the photodegradation study against UVA light, we observed a higher stability of the dithranol-loaded lipid-core nanocapsules comparing to the solution containing the free drug (half-life times around 4 and 1Â h for the dithranol-loaded lipid-core nanocapsules and free drug solution containing EDTA, respectively; half-life times around 17 and 7Â h for the dithranol-loaded lipid-core nanocapsules and free drug solution containing ascorbic acid, respectively). Irritation test by HET-CAM method was conducted to evaluate the safety of the formulations. From the results it was found that the nanoencapsulation of the drug decreased its toxicity compared to the effects observed for the free drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 46, 1 January 2015, Pages 69-76
Journal: Materials Science and Engineering: C - Volume 46, 1 January 2015, Pages 69-76
نویسندگان
Ana L. Savian, Daiane Rodrigues, Julia Weber, Roseane F. Ribeiro, Mariana H. Motta, Scheila R. Schaffazick, Andréa I.H. Adams, Diego F. de Andrade, Ruy C.R. Beck, Cristiane B. da Silva,