کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7869859 1509175 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chitosan/dextran multilayer microcapsules for polyphenol co-delivery
ترجمه فارسی عنوان
میکروکپسول های چند لایه کیتوزان / دکتان برای هماهنگی پلی فنول
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی
Polysaccharide-based nanostructured polymeric microcapsules were fabricated by the electrostatic layer-by-layer self-assembly technique and used to encapsulate mixtures of four different polyphenols in order to achieve their controlled release. The real-time fabrication of the dextran/chitosan multilayer was monitored by quartz crystal microbalance with dissipation monitoring, and the morphology of the nanostructured polymeric capsules was characterized by scanning electron microscopy. The polyphenol encapsulation was obtained by reversible permeability variation of the capsule shell in ethanol:water mixtures. The loading efficiency in different water:ethanol mixtures and the release rate in acidic conditions were characterized by UV spectroscopy and HPLC. The higher loading efficiency was obtained with an ethanol:water 35:65 phenolic solution, equal to 42.0 ± 0.6%, with a total release of 11.5 ± 0.7 mg of total polyphenols per 11.3 μL of microcapsules after 240 min of incubation in acidic environment. The results suggest that polysaccharide-based capsules can be successfully used to encapsulate and release low water-soluble molecules, such as polyphenols.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 46, 1 January 2015, Pages 374-380
نویسندگان
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