کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7885792 | 1509784 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel bi-phase Sr-doped magnesium phosphate/calcium silicate composite scaffold and its osteogenesis promoting effect
ترجمه فارسی عنوان
یک داربست کامپوزیتی دو فاز دوبعدی منیزیم فسفاته / کلسیم سیلیکات و اثر ترویج استئوژنز
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
سرامیک و کامپوزیت
چکیده انگلیسی
In order to improve the osteoconductivity and the osteoinductivity of bone tissue engineering scaffold, a novel bi-phase strontium-doped magnesium phosphate/calcium silicate (Sr-MP/CSC) composite scaffold was fabricated by the self-solidifying/particulate leaching method. The bi-phase composition of the well-crystallized struvite grains wrapped by the calcium silicate floccules was propitious to the deformability and toughness of composite scaffold, and the porous structure with interconnected macropores of 100-400â¯Âµm was beneficial to supporting the tissue growth and transporting nutrients and metabolites. When the Sr-MP/CSC composite scaffolds were degraded in the simulated physiological environment, the doped strontium could be sustainably released together with Ca2+, Mg2+, PO43- and silidous ions. The proliferation and osteogenic differentiation of rat bone marrow stromal cells (BMSCs) on these composite scaffolds were obviously promoted. More valuably, the Sr-doped MP/CSC scaffolds exhibited the more obvious promotion to ALP activity, Col I and OCN expression than the un-doped MP/CSC scaffold, especially in the later stage. The results suggested that the strontium combined with calcium, magnesium and silicon could synergically promote osteogenesis, and the Sr-MP/CSC composite might be one of the promising bone tissue engineering scaffold materials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ceramics International - Volume 44, Issue 14, 1 October 2018, Pages 16237-16245
Journal: Ceramics International - Volume 44, Issue 14, 1 October 2018, Pages 16237-16245
نویسندگان
Shengyi Li, Ximing Pu, Xianchun Chen, Xiaoming Liao, Zhongbing Huang, Guangfu Yin,