Influence of proteins and cells on in vitro corrosion of Mg-Nd-Zn-Zr alloy

The influence of proteins and primary human umbilical vein endothelial cells (HUVECs) coculture on in vitro corrosion of Mg-Nd-Zn-Zr alloy is investigated in this study. Protein supplemented in cell culture medium slows down the corrosion rate of magnesium alloy, while cell coculture accelerates it. Corrosion surface composition is studied using XPS. The Mg-Nd-Zn-Zr alloy shows no adverse effects on cell viability and apoptosis. The mechanisms how proteins and cells affect magnesium alloy corrosion are also discussed.