کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7898510 | 1510138 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Robocast zirconia-toughened alumina scaffolds: Processing, structural characterisation and interaction with human primary osteoblasts
ترجمه فارسی عنوان
داربست آلومینای روکش شده با زیرکونیا روبوکست: پردازش، مشخصات ساختاری و تعامل با استئوبلاست های اولیه انسان
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
سرامیک و کامپوزیت
چکیده انگلیسی
Zirconia-toughened alumina (ZTA) is the gold-standard ceramic in hip arthroplasty, but still lacks direct osseointegration and a metal shell, often coated with a bioactive layer, is currently required. The latter could potentially be replaced by a thinner, architectured ZTA layer, thereby allowing for larger acetabular components, with larger range of motion and lower dislocation risk. Robocasting may be an adequate technique to fabricate the architectured layer. Therefore, as a first step, this study aimed to produce ZTA scaffolds (3D-ZTA) by robocasting and assess their in vitro response. Shape retention was achieved by using a stable, well-dispersed, high solid loading ink injected in acid pH waterbath. 3D-ZTA exhibit regularly spaced microporous, rough struts and fully interconnected macroporosity. Human primary osteoblasts were homogenously distributed inside 3D-ZTA and showed increased osteogenic marker expression compared to 2D-ZTA control. Further work will focus on optimizing scaffold design to improve cell retention and extracellular matrix maturation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the European Ceramic Society - Volume 38, Issue 3, March 2018, Pages 845-853
Journal: Journal of the European Ceramic Society - Volume 38, Issue 3, March 2018, Pages 845-853
نویسندگان
Ana-Maria Stanciuc, Christoph Martin Sprecher, Jérôme Adrien, Lucian Ioan Roiban, Mauro Alini, Laurent Gremillard, Marianna Peroglio,