کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7898563 | 1510138 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Calcium phosphate substrates with emulsion-derived roughness: Processing, characterisation and interaction with human mesenchymal stem cells
ترجمه فارسی عنوان
زیربنای فسفات کلسیم با زبری از امولسیون: پردازش، تعریف و تعامل با سلول های بنیادی مزانشیمی انسان
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کلمات کلیدی
فسفات کلسیم، امولسیون ها، میکروپوریته، زبری سطح، سلول های بنیادی مزانشیمی انسانی،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
سرامیک و کامپوزیت
چکیده انگلیسی
Calcium phosphates (CaP) have been the subject of several studies that often lack a systematic approach to understanding how their properties affect biological response. CaP particles functionalised with a pH-responsive polymer (BCS) were used to prepare microporous substrates (porosity between 70 and 75% and pore sizes of 5-20 μm) through the aggregation of oil-in-water emulsions by controlling solid loading, emulsification energy, pH, drying and sintering conditions. The combined effect of surface roughness (roughness amplitude, Ra between 0.9-1.7 μm) and chemistry (varying Hydroxyapatite/β-Tricalcium phosphate ratio) on human mesenchymal stem cells was evaluated. HA substrates stimulated higher cell adhesion and proliferation (especially with lower Ra), but cell area increased with β-TCP content. The effect of surface roughness depended of chemistry: HA promoted higher mineralising activity when Ra â¼Â 1.5 μm, whereas β-TCP substrates stimulated a more osteogenic profile when Ra â¼Â 1.7 μm. A novel templating method to fabricate microporous CaP substrates was developed, opening possibilities for bone substitutes with controlled features.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the European Ceramic Society - Volume 38, Issue 3, March 2018, Pages 949-961
Journal: Journal of the European Ceramic Society - Volume 38, Issue 3, March 2018, Pages 949-961
نویسندگان
Gil Costa Machado, Esther GarcÃa-Tuñón, Robert V. Bell, Mauro Alini, Eduardo Saiz, Marianna Peroglio,