Computer aided measurement of sub-epithelial collagen band in colon biopsies for collagenous colitis diagnosis

► For the first time, a CAD algorithm for Collagenous Colitis diagnosis is proposed. ► The proposed method helps pathologists evaluate colon samples more accurately. ► Proposed method explores the best set of features from different descriptors. ► In this algorithm a pre-trained MLP neural network is used for classification. ► To achieve robustness against false positives, an index named STD is presented.