کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8014786 1517173 2018 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A simple way of modulating in vitro angiogenic response using Cu and Co-doped bioactive glasses
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد فناوری نانو (نانو تکنولوژی)
پیش نمایش صفحه اول مقاله
A simple way of modulating in vitro angiogenic response using Cu and Co-doped bioactive glasses
چکیده انگلیسی
The copper and cobalt-doped bioactive glasses (BGs) from the basic SiO2-CaO-P2O5 system, differing in the CaO/SiO2 molar ratios, were produced using sol-gel method. The in vitro angiogenic response of human fibroblasts and umbilical vein endothelial cells (HUVECs) on Cu-BGs and Co-BGs was investigated. The incorporation of Cu and Co into BGs significantly enhanced vascular endothelial growth factor secretion from fibroblasts. Cu-BGs and Co-BGs extracts might facilitate the migration of HUVECs and the self-assembled network formation after 3 days of culture without basement membrane matrix, demonstrating strong angiogenic activity. The results show that cellular response was correlated with Cu and Co release rate which, in turn, was affected by the CaO/SiO2 molar ratios, indicating new opportunities for controlling the release rate of therapeutic ions from BGs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Letters - Volume 215, 15 March 2018, Pages 87-90
نویسندگان
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