A new combined approach to metal-ceramic implants with controllable surface topography, chemistry, blind porosity, and wettability

► Biocompatible materials with controllable surface topography, porosity, and chemical composition. ► Ti materials with roughness 4-80 μm and blind pore volumes (1.0-5.1) × 10− 3 mm3. ► Surface parameters influence adhesion, spreading, growth, and differentiation of osteoblasts. ► Bioactivity of Ti surface is controlled by the surface chemistry and topography. ► Metal-ceramic coatings on orthopedic implants with microcontainers for medicine.