Production of medical radioisotope 153Sm in the Tehran Research Reactor (TRR) through theoretical calculations and practical tests

► Production of 153Sm isotope by neutron activation in a nuclear reactor was studied. ► Optimal parameters for weight and irradiation time were found. ► This study led to an empirical correction factor (kf). ► Kf enhanced the production procedure of the 153Sm radioisotope. ► The results led to nearly 60% decrease in the amount of material used in the production process.