کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
807799 | 1468293 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
QCM-based rapid analysis of DNA
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: QCM-based rapid analysis of DNA QCM-based rapid analysis of DNA](/preview/png/807799.png)
چکیده انگلیسی
We demonstrated that it is possible to break apart double-stranded DNA using a thickness shear mode resonator. This procedure measures the force of bond rupture. The measured rupture forces were in the range of 10–40 pN. The procedure was tested experimentally with model complementary and non-complementary oligonucleotides. In the case of the DNA mismatch we observed a signal at a driving voltage of 0.8 V (corresponding to a shear force of 11 pN), while in the case of complementarity the signal at the voltage of 3 V (36 pN) appeared. This procedure may be the ground for the development of new types of biosensors measuring the force of affine interactions (probe/biomolecular target) on the surface of the sensor element.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensing and Bio-Sensing Research - Volume 4, June 2015, Pages 11–15
Journal: Sensing and Bio-Sensing Research - Volume 4, June 2015, Pages 11–15
نویسندگان
F.N. Dultsev, E.A. Kolosovsky, M.A. Cooper, A.A. Lomzov, D.V. Pyshnyi,