Assessing model parameter uncertainties for rising velocity of CO2 droplets through experimental design

► A CO2 leak to marine waters from a storage site might impose environmental impacts. ► An important sub-model for simulating the faith of the seep is the rise velocity. ► We assess uncertainties in a previously executed parameter estimation experiment. ► An experimental design, reducing the parameter uncertainties with up to 63%, is suggested. ► Model/experiment interaction in parameter estimation experiments is important.