کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8208410 1532058 2018 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In-house cyclotron production of high-purity Tc-99m and Tc-99m radiopharmaceuticals
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
In-house cyclotron production of high-purity Tc-99m and Tc-99m radiopharmaceuticals
چکیده انگلیسی
In this study, it is conjectured that this alternative production route will not replace the current supply chain based on the distribution of 99Mo/99mTc generators, but could become a convenient emergency source of Tc-99m only for in-house hospitals equipped with a conventional, low-energy, medical cyclotron. On this ground, an outline of the essential steps that should be implemented for setting up a hospital radiopharmacy aimed at the occasional production of Tc-99m by a small cyclotron is discussed. These include (1) target production, (2) irradiation conditions, (3) separation/purification procedures, (4) terminal sterilization, (5) quality control, and (6) Mo-100 recovery. To address these issues, a comprehensive technology for cyclotron-production of Tc-99m, developed at the Legnaro National Laboratories of the Italian National Institute of Nuclear Physics (LNL-INFN), will be used as a reference example.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 139, September 2018, Pages 325-331
نویسندگان
, , , , , , , , , , , , , , ,