کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8208410 | 1532058 | 2018 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In-house cyclotron production of high-purity Tc-99m and Tc-99m radiopharmaceuticals
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study, it is conjectured that this alternative production route will not replace the current supply chain based on the distribution of 99Mo/99mTc generators, but could become a convenient emergency source of Tc-99m only for in-house hospitals equipped with a conventional, low-energy, medical cyclotron. On this ground, an outline of the essential steps that should be implemented for setting up a hospital radiopharmacy aimed at the occasional production of Tc-99m by a small cyclotron is discussed. These include (1) target production, (2) irradiation conditions, (3) separation/purification procedures, (4) terminal sterilization, (5) quality control, and (6) Mo-100 recovery. To address these issues, a comprehensive technology for cyclotron-production of Tc-99m, developed at the Legnaro National Laboratories of the Italian National Institute of Nuclear Physics (LNL-INFN), will be used as a reference example.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 139, September 2018, Pages 325-331
Journal: Applied Radiation and Isotopes - Volume 139, September 2018, Pages 325-331
نویسندگان
Petra Martini, Alessandra Boschi, Gianfranco Cicoria, Federico Zagni, Andrea Corazza, Licia Uccelli, Micòl Pasquali, Gaia Pupillo, Mario Marengo, Massimo Loriggiola, Hanna Skliarova, Liliana Mou, Sara Cisternino, Sara Carturan, Laura Melendez-Alafort,