کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8209114 1532079 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A mild, rapid synthesis of freebase [11C]nicotine from [11C]methyl triflate
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
A mild, rapid synthesis of freebase [11C]nicotine from [11C]methyl triflate
چکیده انگلیسی
A rapid, mild radiosynthesis of freebase [11C]nicotine was developed by the methylation of freebase nornicotine with [11C]methyl triflate in acetone (5 min, 45 °C). A basic (pH 10.5-11.0) HPLC system reproducibly yielded freebase [11C]nicotine as a well-defined single peak. The freebase [11C]nicotine was concentrated by solid phase extraction and formulated in 50 µL ethanol (370 MBq/50 µL) without evaporative loss suitable for a cigarette spiking study. A radiochemical yield of 60.4±4.7% (n=3), radiochemical purity ≥99.9% and specific activity of 648 GBq/µmol at EOB for 5 min beams were achieved.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 118, December 2016, Pages 62-66
نویسندگان
, , , , , ,