Separation of [99mTc]pertechnetate and molybdate using polyethylene glycol coated C18 and C30 resins

Hydrophobic adsorbents such as C18 and C30 were coated with PEG and subsequently used for the separation of Mo/Tc. The most effective resin for adsorbing PEG was the C18-U resin, which demonstrated a coating capacity of 97.6±2.8 mg PEG per g of resin. The ability to adsorb pertechnetate was proportional to the amount of PEG coated on the hydrophobic resin. The [99mTc]pertechnetate recovery during the separation of cyclotron produced 99mTc from 100Mo was 91.8±0.3% (n=2). The resultant product met relevant USP monograph specifications.