Automated radiosynthesis of [11C]L-deprenyl-D2 and [11C]D-deprenyl using a commercial platform

Two 11C-labelled PET tracers, (R)-N-[11C]methyl-N-(3,3-dideuteropropargyl)-1-phenylpropan-2-amine ([11C]L-deprenyl-D2, [11C]DED) and (S)-N-[11C]methyl-N-propargyl-1-phenylpropan-2-amine ([11C]D-deprenyl, [11C]DDE) were synthesised. One step N-alkylation with [11C]MeI or [11C]MeOTf was performed using the automated platform TRACERlab® FX-C Pro. The labelled products were obtained with (37±15)% (n=10) (end of synthesis, decay corrected from [11C]MeI) radiochemical yields from [11C]MeI after 38±3 min synthesis time. In all cases, radiochemical purity was over 99% when [11C]MeOTf was used. This synthesis using a commercial platform makes these tracers more accessible for clinical research purposes.