کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8209365 | 1532088 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Radionuclidic purity tests in 18F radiopharmaceutIcals production process
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Radionuclidic purity tests of 18F radiopharmaceuticals (Na18F and fluorodeoxyglucose [18F]FDG) and radionuclide composition analysis of irradiated water [18O]H2O were performed. The measurements were conducted using a High-Purity Germanium (HPGe) detector and a liquid scintillation counter. Radionuclide identification and activity measurements were performed for samples from different stages of the production process. Most of the impurities were detected on QMA (quaternary methylammonium) anion exchange columns and in liquid wastes. Using liquid scintillation counting, the activity of 3H resulting from the 18O[p, 3H]16O reaction was determined. It was shown that all of the impurities were efficiently determined and eliminated in the radiopharmaceuticals synthesis process and that the final products meet the requirements set by relevant regulations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 109, March 2016, Pages 242-246
Journal: Applied Radiation and Isotopes - Volume 109, March 2016, Pages 242-246
نویسندگان
Tomasz Dziel, Zbigniew TymiÅski, Katarzyna Sobczyk, Agata WalÄcka-Mazur, PrzemysÅaw Kozanecki,