کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8209586 1532091 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biokinetic analysis of tissue boron (10B) concentrations of glioma patients treated with BNCT in Finland
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Biokinetic analysis of tissue boron (10B) concentrations of glioma patients treated with BNCT in Finland
چکیده انگلیسی
A total of 98 patients with glioma were treated with BPA-F-mediated boron neutron capture therapy (BNCT) in Finland from 1999 to 2011. Thirty-nine (40%) had undergone surgery for newly diagnosed glioblastoma and 59 (60%) had malignant glioma recurrence after surgery. In this study we applied a closed 3-compartment model based on dynamic 18F-BPA-PET studies to estimate the BPA-F concentrations in the tumor and the normal brain with time. Altogether 22 patients with recurrent glioma, treated within the context of a clinical trial, were evaluated using their individual measured whole blood 10B concentrations as an input to the model. The delivered radiation doses to tumor and the normal brain were recalculated based on the modeled 10B concentrations in the tissues during neutron irradiation. The model predicts from −7% to +29% (average, +11%) change in the average tumor doses as compared with the previously estimated doses, and from 17% to 61% (average, 36%) higher average normal brain doses than previously estimated due to the non-constant tumor-to-blood concentration ratios and considerably higher estimated 10B concentrations in the brain at the time of neutron irradiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 106, December 2015, Pages 189-194
نویسندگان
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