کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8210531 | 1532114 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Easy upgrade of the TRACERLab FX C Pro for [11C]carboxylation reactions: Application to the routine production of [1-11C]acetate
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
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چکیده انگلیسی
Carbon-11-labeled acetate ([1-11C]acetate) is a radiopharmaceutical of importance in clinical practice as well as in preclinical research in cardiology and oncology. Its preparation is based on the [11C]carboxylation reaction of a Grignard reagent with [11C]CO2. Most of the commercially available synthesizers are only dedicated to the preparation of [11C]methyl iodide (or [11C]methyl triflate) for the radiomethylation of an appropriate precursor but not for the direct use of cyclotron-produced [11C]CO2. Based on the classical [11C]carboxylation reaction and SPE purification, we propose in this technical note a detailed, simple, easy-to-handle and fully reversible modification of the TRACERLab FX C Pro to operate, on demand, [11C]carboxylation reactions, exemplified herein by the production of [1-11C]acetate, or [11C]radiomethylation reactions. This also opens new prospects to other type of radiochemical reactions involving [11C]CO2.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 82, December 2013, Pages 7-11
Journal: Applied Radiation and Isotopes - Volume 82, December 2013, Pages 7-11
نویسندگان
Stéphane Le Helleix, Frédéric Dollé, Bertrand Kuhnast,