Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targeting

A New 18F-Labeled Styryl Benzoxazole Derivative ([18F]-1) for β-Amyloid Targeting has been synthesized in good radiochemical yield and high radiochemical purity (>99%, both isomers. Biodistribution and metabolism studies of 18F]-1 in male Wistar rats have shown that this new radiotracer can cross the BBB but has a poor in vivo stability.