Metabolic Imaging Biomarkers of Postradiotherapy Xerostomia

In this pilot series, loss of parotid FDG uptake was strongly associated with acute clinical post-RT parotid toxicity. DMet may potentially be used to guide function-sparing treatment planning. Prospective validation of FDG-PET-CT as a convenient, quantifiable imaging biomarker of parotid function is warranted and ongoing.