Cervical Cancer Regression Measured Using Weekly Magnetic Resonance Imaging During Fractionated Radiotherapy: Radiobiologic Modeling and Correlation With Tumor Hypoxia

The results of our study have shown that cervical cancer regresses during external beam radiotherapy, although marked variability is present among patients and is influenced by underlying biologic processes, including cellular sensitivity to radiotherapy and proliferation. Better understanding of the biologic mechanisms might facilitate novel adaptive treatment strategies in future studies.