کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8241313 1533150 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Radioprotective Effects of Amifostine on Acute and Chronic Esophageal Injury in Rodents
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Radioprotective Effects of Amifostine on Acute and Chronic Esophageal Injury in Rodents
چکیده انگلیسی
This study demonstrates that amifostine given before each radiation fraction protects against acute and chronic esophageal injury in a rodent model. Protection of the mucosal epithelium integrity by amifostine prevents integrinαvβ6 expression which reduces TGF-β activation and subsequent development of chronic esophageal injury in this model. Further investigation is necessary to determine the clinical relevance of these findings.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Radiation Oncology*Biology*Physics - Volume 69, Issue 2, 1 October 2007, Pages 534-540
نویسندگان
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