French multicenter phase III randomized study testing concurrent twice-a-day radiotherapy and cisplatin/5-fluorouracil chemotherapy (BiRCF) in unresectable pharyngeal carcinoma: Results at 2 years (FNCLCC-GORTEC)

Conclusion: For these unresectable cases, chemoradiation provides better outcome than radiation alone, even with an “aggressive” dose-intensity radiotherapy schedule.