Measurement of activation products generated in the [18F]FDG production by a 9.6Â MeV cyclotron

Gamma-ray spectrometry was used for the identification and quantification of the activation products induced during the production of [18F]FDG in a cyclotron with a beam of 9.6 MeV protons, a silver target and Havar entrance window. Samples of the irradiated water collected before and after the 18F separation, and of the final product [18F]FDG were measured in the particular conditions of a beam current of 45 μA and an irradiation time of 25-30 min The radionuclides 52Mn, 55Co, 56Co, 57Co, 58Co, 95Tc, 96Tc, and 109Cd were identified in the irradiated water samples, but not detected in the final [18]FDG product. The requirements for the transport of the recovered enriched water are also discussed.