کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8257257 | 1534312 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Consistent age-dependent declines in human semen quality: A systematic review and meta-analysis
ترجمه فارسی عنوان
کاهش پایدار وابسته به سن در کیفیت مایع منی: بررسی منظم و متا آنالیز
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کلمات کلیدی
REMLMEMAREMALMMPRISMAROS - ROSPreferred Reporting Items for Systematic Reviews and Meta-Analyses - آیتم های گزارش مورد نظر برای بررسی های سیستماتیک و متا آنالیزFertility - باروریintracytoplasmic sperm injection - تزریق اسپرم داخلسیتوپلاسمیGross domestic product - تولید ناخالص داخلیGDP - تولید ناخالص ملیCASA - خانهMeta-regression - رگرسیون متا ریاضیWorld Health Organization - سازمان بهداشت جهانیpaternal age - سن پدرQuantitative synthesis - سنتز کمیIn vitro fertilization - لقاح در خارج از بدن یا آیویافIVF - لقاح مصنوعی Restricted maximum likelihood - محدودیت حداکثر احتمالLinear mixed-effects model - مدل های ترکیبی اثر خطیICSI - میکرواینجکشنmale aging - پیری مردWHO - کهReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Reduced fertility typically occurs among women in their late 30s, but increasing evidence indicates that advanced paternal age is associated with changes in reproduction as well. Numerous studies have investigated age-based declines in semen traits, but the impact of paternal age on semen parameter values remains inconclusive. Using data from 90 studies (93,839 subjects), we conducted a systematic review and meta-analysis to quantify the effect of male age on seven ejaculate traits (semen volume, sperm concentration, total sperm count, morphology, total motility, progressive motility and DNA fragmentation). Age-associated declines in semen volume, percentage motility, progressive motility, normal morphology and unfragmented cells were statistically significant and results generally seemed to be robust against confounding factors. Unexpectedly, sperm concentration did not decline with increasing male age, even though we found that sperm concentration declined over time. Our findings indicate that male age needs more recognition as a potential contributor to the negative pregnancy outcomes and reduced offspring health associated with delayed first reproduction. We suggest that greater focus on collection of DNA fragmentation and progressive motility in a clinical setting may lead to better patient outcomes during fertility treatments of aging couples.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 19, January 2015, Pages 22-33
Journal: Ageing Research Reviews - Volume 19, January 2015, Pages 22-33
نویسندگان
Sheri L. Johnson, Jessica Dunleavy, Neil J. Gemmell, Shinichi Nakagawa,