Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

- Review of age related processes occurring within substantia nigra neurons.
- Discussion of why these neurons seem to be susceptible to loss with age.
- Review of why SN neurons are particularly sensitive to mitochondrial dysfunction.
- Review of why SN neurons are sensitive to changes in protein degradation pathways.
- Discussion of relevance to Parkinson's disease pathology.