کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8257385 | 1534411 | 2018 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cardiovascular symptoms and longitudinal declines in processing speed differentially predict cerebral white matter lesions in older adults
ترجمه فارسی عنوان
علائم قلب و عروق و کاهش طولی در سرعت پردازش به طور متفاوتی پیش بینی ضایعات ماده مغزی در افراد مسن است
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کلمات کلیدی
ضایعات ماده سفید، کاهش شناختی، سالخورده، سرعت پردازش، تجزیه و تحلیل جنگل تصادفی، فراگیری ماشین،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
It is well established that cerebral white matter lesions (WML), present in the majority of older adults, are associated with cardiovascular and cerebrovascular diseases and also with cognitive decline. However, much less is known about how WML are related to other important individual characteristics and about the generality vs. brain region-specificity of WML. In a longitudinal study of 112 community-dwelling adults (age 50-71â¯years at study entry), we used a machine learning approach to evaluate the relative strength of 52 variables in association with WML burden. Variables included socio-demographic, lifestyle, and health indices-as well as multiple cognitive abilities (modeled as latent constructs using factor analysis)-repeatedly measured at three- to six-year intervals. Greater chronological age, symptoms of cardiovascular disease, and processing speed declines were most strongly linked to elevated WML burden (accounting for â¼49% of variability in WML). Whereas frontal lobe WML burden was associated both with elevated cardiovascular symptoms and declines in processing speed, temporal lobe WML burden was only significantly associated with declines in processing speed. These latter outcomes suggest that age-related WML-cognition associations may be etiologically heterogeneous across fronto-temporal cerebral regions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Gerontology and Geriatrics - Volume 78, SeptemberâOctober 2018, Pages 139-149
Journal: Archives of Gerontology and Geriatrics - Volume 78, SeptemberâOctober 2018, Pages 139-149
نویسندگان
Stephen Aichele, Patrick Rabbitt, Paolo Ghisletta,