کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8262280 | 1534834 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Relationship between high sodium and low PUFA intake and carotid atherosclerosis in elderly women
ترجمه فارسی عنوان
ارتباط مصرف زیاد پتاسیم و پتاسیم و آترواسکلروز کاروتید در زنان سالمند
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Several biologically active molecules including nutrients can affect the vascular endothelium which becomes dysfunctional and, as a consequence, predisposes to atherosclerosis. However, the impact of the intake of sodium and polyunsaturated fatty acids on carotid atherosclerosis in a population of elderly women has scarcely been studied. Our aim was to investigate the association between carotid intima-media thickness and atherosclerotic plaque and nutrient intake in asymptomatic elderly women. Carotid atherosclerosis was determined by duplex ultrasound in 108 elderly women. Dietary intake was assessed by a combination of a 24-hour recall and a 7-day food record. A physical examination and laboratory tests were performed. We found an association between the C-IMT and polyunsaturated fatty acid (negative, Bâ¯=â¯â0.014; pâ¯=â¯0.03; CI â0.027/â0.001) and sodium (positive, râ¯=â¯0.16; Pâ¯=â¯0.09) intake. When linoleic acid was added to the multivariable regression analysis instead of polyunsaturated fatty acids, C-IMT was associated with linoleic acid (Bâ¯=â¯â0.017; pâ¯=â¯0.02; CI â0.032/â0.003). In normotensive women we found a positive association between the C-IMT and sodium intake. The atherosclerotic plaque prevalence increased with the increase in sodium intake (66% vs 90% Tertile I vs Tertile III; pâ¯=â¯0.02). Iin conclusion, A low salt diet to a level of about 1.5â¯g/d and a polyunsaturated fatty acid intake of >9â¯g/d were found to be associate with a low atherosclerotic plaque prevalence in an elderly female population. Sodium and polyunsaturated fatty acids-mediated functional changes of the carotid endothelium may be implicated in atherosclerosis development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 108, 15 July 2018, Pages 256-261
Journal: Experimental Gerontology - Volume 108, 15 July 2018, Pages 256-261
نویسندگان
Elisa Mazza, Yvelise Ferro, Theodora Lamprinoudi, Carmine Gazzaruso, Patrizia Doldo, Arturo Pujia, Tiziana Montalcini,