کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8263800 | 1534878 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of in vivo loading on bone composition varies with animal age
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Loading can increase bone mass and size and this response is reduced with aging. It is unclear, however how loading affects bone mineral and matrix properties. Fourier transform infrared imaging and high resolution synchrotron scanning small angle X-ray scattering were used to study how bone's microscale and nanoscale compositional properties were altered in the tibial midshaft of young, adult, and elderly female C57Bl/6J mice after two weeks of controlled in vivo compressive loading in comparison to physiological loading. The effect of controlled loading on bone composition varied with animal age, since it predominantly influenced the bone composition of elderly mice. Interestingly, controlled loading led to enhanced collagen maturity in elderly mice. In addition, although the rate of bone formation was increased by controlled loading based on histomorphometry, the newly formed tissue had similar material quality to the new bone tissue formed during physiological loading. Similar to previous studies, our data showed that bone composition was animal age- and tissue age-dependent during physiological loading. The findings that the new tissue formed in response to controlled loading and physiological loading had similar bone composition and that controlled loading enhanced bone composition in elderly mice further support the use of physical activity as a noninvasive treatment to enhance bone quality as well as maintain bone mass in individuals suffering from age-related bone loss.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 63, March 2015, Pages 48-58
Journal: Experimental Gerontology - Volume 63, March 2015, Pages 48-58
نویسندگان
Marta Aido, Michael Kerschnitzki, Rebecca Hoerth, Sara Checa, Lyudmila Spevak, Adele L. Boskey, Peter Fratzl, Georg N. Duda, Wolfgang Wagermaier, Bettina M. Willie,