کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8264715 1534892 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased Th17 differentiation in aged mice is significantly associated with high IL-1β level and low IL-2 expression
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Increased Th17 differentiation in aged mice is significantly associated with high IL-1β level and low IL-2 expression
چکیده انگلیسی
We demonstrated that the proportion of Th17 cells increased in the aged mice both in naïve and memory cell populations. Elevation of IL-1R and IL-1β expression and the reduction in IL-2 and IL-2R expression in aged mice seemed to promote Th17 differentiation. Our results suggest that enhanced Th17 differentiation in aging may have a pathogenic role in the development of Th17-mediated autoimmune diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 49, January 2014, Pages 55-62
نویسندگان
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