The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies

► ATN-224 decreases SOD1 and CcOX activity in lymphoma cell culture models. ► ATN-224 induces death independent of antioxidant defense enzyme and Bcl-2 levels. ► ATN-224 increases oxidants and induces peroxynitrite-dependent cell death. ► Primary B-cell acute lymphoblastic leukemia cells were sensitive to ATN-224.