Loss of p53 in stromal fibroblasts promotes epithelial cell invasion through redox-mediated ICAM1 signal

► Loss of p53 in stromal fibroblasts upregulates eNOS and increases NO and RNS production. ► Elevated NO and RNS in the fibroblasts upregulates ICAM1, promoting epithelial cell invasion. ► Knocking down eNOS in the fibroblasts suppresses ICAM1 synthesis and prevents epithelial invasion. ► Suppressing NO and RNS with antioxidant blocks ICAM1 synthesis and prevents epithelial invasion. ► Modulation of redox signaling in stroma may be a novel strategy to prevent epithelial invasion.