Oxidative stress mediates chemerin-induced autophagy in endothelial cells

► Chemerin has augmented autophagy roles in endothelial cells. ► Mitochondrial reactive oxygen species are important for chemerin-induced autophagy. ► Chemerin induces autophagy through the AMPKα and beclin-1 pathways. ► Oxidative stress-mediated autophagy is involved in chemerin-induced angiogenesis.