کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8271776 | 1534990 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biomarkers of oxidative damage in cigarette smokers: Which biomarkers might reflect acute versus chronic oxidative stress?
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کلمات کلیدی
CoPS8OHdGF2-IsoPF4-neuroprostanes8-hydroxy-2′-deoxyguanosine - 8-هیدروکسی-2'-دگزسی گوانوزینF2-isoprostane - F2-ایزوپروستانGC/MS - GC / MSROS - ROSIsoprostanes - ایزوپروتامین هاOxidative stress - تنش اکسیداتیوFree radicals - رادیکال آزادCholesterol oxidation products - محصولات اکسیداسیون کلسترولcigarette smoking - مصرف سیگارHETE - هفتهReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Cigarette smoking predisposes to the development of multiple diseases involving oxidative damage. We measured a range of oxidative damage biomarkers to understand which differ between smokers and nonsmokers and if the levels of these biomarkers change further during the act of smoking itself. Despite overnight abstinence from smoking, smokers had higher levels of plasma total and esterified F2-isoprostanes, hydroxyeicosatetraenoic acid products (HETEs), F4-neuroprostanes, 7-ketocholesterol, and 24- and 27-hydroxycholesterol. Levels of urinary F2-isoprostanes, HETEs, and 8-hydroxy-2â²-deoxyguanosine were also increased compared with age-matched nonsmokers. Several biomarkers (plasma free F2-isoprostanes, allantoin, and 7β-hydroxycholesterol and urinary F2-isoprostane metabolites) were not elevated. The smokers were then asked to smoke a cigarette; this acute smoking elevated plasma and urinary F2-isoprostanes, plasma allantoin, and certain cholesterol oxidation products compared to presmoking levels, but not plasma HETEs or urinary 8-hydroxy-2â²-deoxyguanosine. Smokers showed differences in plasma fatty acid composition. Our findings confirm that certain oxidative damage biomarkers are elevated in smokers even after a period of abstinence from smoking, whereas these plus some others are elevated after acute smoking. Thus, different biomarkers do not measure identical aspects of oxidative stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 50, Issue 12, 15 June 2011, Pages 1787-1793
Journal: Free Radical Biology and Medicine - Volume 50, Issue 12, 15 June 2011, Pages 1787-1793
نویسندگان
Raymond C.S. Seet, Chung-Yung J. Lee, Wai Mun Loke, Shan Hong Huang, Huiwen Huang, Woan Foon Looi, Eng Soh Chew, Amy M.L. Quek, Erle C.H. Lim, Barry Halliwell,