کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8274702 1535099 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The difference of apparent diffusion coefficient in the middle cerebellar peduncle among parkinsonian syndromes: Evidence from a meta-analysis
ترجمه فارسی عنوان
تفاوت ضریب نفوذ آشکار در ستون فقرات متوسط ​​در میان سندرم های پارکینسونی: شواهدی از یک متاآنالیز
کلمات کلیدی
بیماری پارکینسون، آتروفی سیستم چندگانه، فلج هسته ای پیشرو، میانه مخچه مدیترانه، ضریب انتشار آشکار، متاآنالیز،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
The measurement of middle cerebellar peduncle (MCP) width allows for differential diagnosis between Parkinson's disease (PD) and multiple system atrophy with predominant parkinsonian features (MSA-P). However, it remains controversial whether apparent diffusion coefficient (ADC) value in the MCP of MSA-P is elevated or not. In the present study, we aimed to assess the usefulness of ADC value in the MCP for differential diagnosis between PD and MSA-P. An on-line literature search yielded 5 eligible studies. We expressed between-group difference of ADC value as the standardized mean difference (SMD). The proportion of variation due to heterogeneity was computed and expressed as I2. ADC in the MCP of MSA-P was significantly increased compared with PD with heterogeneous studies (P = 0.0007, I2 = 81%). A meta-regression analysis of MSA-P was conducted for “UPDRS III”, and revealed a significant correlation between UPDRS III and SMD (P = 0.01). Our meta-regression analysis has clarified the contribution of severity of MSA-P to heterogeneity of the included studies for ADC in the MCP. This finding raised the possibility that ADC in the MCP depended on severity of MSA-P, and less severe patients with MSA-P should be mainly enrolled in future study to assess the ability for differential diagnostic tool.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 363, 15 April 2016, Pages 90-94
نویسندگان
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