کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8284416 | 1535299 | 2016 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Vitamin D may be involved in ocular function in older adults, but there is no current consensus on a possible association between circulating concentrations of 25-hydroxyvitamin D (25OHD) and the occurrence of age-related macular degeneration (AMD). Our objective was to systematically review and quantitatively assess the association of circulating 25OHD concentration with AMD. A Medline search was conducted in November 2015, with no date limit, using the MeSH terms “Vitamin D” OR “Vitamin D deficiency” OR “Ergocalciferols” OR 'Cholecalciferol' combined with “Age-related macular degeneration” OR “Macular degeneration” OR “Retinal degeneration” OR “Macula lutea” OR “Retina”. Fixed and random-effects meta-analyses were performed to compute (i) standard mean difference in 25OHD concentration between AMD and non-AMD patients; (ii) AMD risk according to circulating 25OHD concentration. Of the 243 retrieved studies, 11 observational studies-10 cross-sectional studies and 1 cohort study-met the selection criteria. The number of participants ranged from 65 to 17,045 (52-100% women), and the number with AMD ranged from 31 to 1440. Circulating 25OHD concentration was 15% lower in AMD compared with non-AMD on average. AMD was inversely associated with the highest 25OHD quintile compared with the lowest (summary odds ratio (OR)Â =Â 0.83 [95%CI:0.71-0.97]), notably late AMD (summary ORÂ =Â 0.47 [95%CI:0.28-0.79]). Circulating 25OHDÂ <Â 50Â nmol/L was also associated with late-stage AMD (summary ORÂ =Â 2.18 [95%CI:1.34-3.56]), an association that did not persist when all categories of AMD were considered (summary ORÂ =Â 1.26 [95%CI:0.90-1.76]). In conclusion, this meta-analysis provides evidence that high 25OHD concentrations may be protective against AMD, and that 25OHD concentrations below 50Â nmol/L are associated with late AMD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Maturitas - Volume 88, June 2016, Pages 101-112
Journal: Maturitas - Volume 88, June 2016, Pages 101-112
نویسندگان
Cedric Annweiler, Morgane Drouet, Guillaume T Duval, Pierre-Yves Paré, Stephanie Leruez, Mickael Dinomais, Dan Milea,