کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8286506 1535835 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Post-translational regulation of macrophage migration inhibitory factor: Basis for functional fine-tuning
ترجمه فارسی عنوان
تنظیم مقدماتی پس از انتقال عوامل مهارکننده مهاجرت ماکروفاژها: مبنای تنظیم دقیق عملکرد
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Macrophage migration inhibitory factor (MIF) is a chemokine-like protein and an important mediator in the inflammatory response. Unlike most other pro-inflammatory cytokines, a number of cell types constitutively express MIF and secretion occurs from preformed stores. MIF is an evolutionarily conserved protein that shows a remarkable functional diversity, including specific binding to surface CD74 and chemokine receptors and the presence of two intrinsic tautomerase and oxidoreductase activities. Several studies have shown that MIF is subject to post-translational modification, particularly redox-dependent modification of the catalytic proline and cysteine residues. In this review, we summarize and discuss MIF post-translational modifications and their effects on the biological properties of this protein. We propose that the redox-sensitive residues in MIF will be modified at sites of inflammation and that this will add further depth to the functional diversity of this intriguing cytokine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Redox Biology - Volume 15, May 2018, Pages 135-142
نویسندگان
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