کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8326839 | 1540196 | 2018 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing
ترجمه فارسی عنوان
هیدروژل ترکیبی سلولز-لیگنین باکتریایی به عنوان یک عامل امیدوارکننده در بهبود زخم مزمن
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کلمات کلیدی
پلیمر مدل لیگنین، سلولز باکتریایی، فعالیت ضد میکروبی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24â¯h there was still slow release of small amounts of DHP from BC-DHP during 72â¯h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 118, Part A, 15 October 2018, Pages 494-503
Journal: International Journal of Biological Macromolecules - Volume 118, Part A, 15 October 2018, Pages 494-503
نویسندگان
Danica Zmejkoski, Dragica SpasojeviÄ, Irina Orlovska, Natalia Kozyrovska, Marina SokoviÄ, Jasmina GlamoÄlija, Svetlana DmitroviÄ, Branko MatoviÄ, Nikola TasiÄ, Vuk MaksimoviÄ, Mikhail Sosnin, Ksenija RadotiÄ,