کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8326871 1540196 2018 37 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Magnetic nanocellulose alginate hydrogel beads as potential drug delivery system
ترجمه فارسی عنوان
دانه های هیدروژل آلژینات مغناطیسی نانو سلولز به عنوان سیستم تحویل به داروهای بالقوه
کلمات کلیدی
نانوبلورهای سلولز مغناطیسی، دانه های هیدروژل آلژینات، پوسته برنج، تحویل مواد مخدر، ایبوپروفن
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Magnetic nanocellulose alginate hydrogel beads are produced from the assembly of alginate and magnetic nanocellulose (m-CNCs) as a potential drug delivery system. The m-CNCs were synthesized from cellulose nanocrystals (CNCs) that were isolated from rice husks (RH) by co-precipitation method and were incorporated into alginate-based hydrogel beads with the aim of enhancing mechanical strength and regulating drug release behavior. Ibuprofen was chosen as a model drug. The prepared CNCs, m-CNCs and the alginate hydrogel beads were characterized by various physicochemical techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM) and vibrating sample magnetometer studies (VSM). Besides the magnetic property, the presence of m-CNCs increased the integrity of the alginate hydrogel beads and the swelling percentage. The drug release study exhibited a controlled release profiles and based on the drug release data, the drug release mechanism was analyzed and discussed based on mathematical models such as Korsmeyer-Peppas and Peppas-Sahlin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 118, Part A, 15 October 2018, Pages 640-648
نویسندگان
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