Modification of sterculia gum polysaccharide via network formation by radiation induced crosslinking polymerization for biomedical applications

The release profile of anti-cancer drug “gemcitabine” followed non-Fickian diffusion mechanism and release profile was best fitted in Korsmeyer-Peppas kinetic model of drug release. The hydrogels were found to be non-thrombogenic, non-haemolytic, mucoadhesive and antioxidant in nature. Incorporation of the GO nano-sheets in the composite hydrogel matrix has improved its mechanical and drug delivery properties and also exerted strong influence on the network density and mesh size of the hydrogels.