کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8327470 1540201 2018 47 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and characterization of basil seed mucilage coated Fe3O4 magnetic nanoparticles as a drug carrier for the controlled delivery of cephalexin
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Synthesis and characterization of basil seed mucilage coated Fe3O4 magnetic nanoparticles as a drug carrier for the controlled delivery of cephalexin
چکیده انگلیسی
A novel drug delivery system, loaded the drug cephalexin on the basil seed mucilage coated magnetic nanoparticles (Fe3O4@BSM-CPX) was prepared and characterized by means of X-ray diffraction (XRD), Furier Transform Infrared (FTIR), Field Emission Scanning Electron Microscope (FESEM), Vibrating Sample Magnetometer (VSM), Transmission Electron Microscopy (TEM), and Anti-bacterial, and Specific Surface (BET). By comparing the size of the uncoated nanoparticles (12 nm) and the size of the coated magnetite nanoparticles (6 nm), it was found that with the mucilage coating being put on the magnetite nanoparticles, the size of the nanoparticle cores has also decreased. The optimum pH results showed that the higher adsorption capacity occurs when cephalexin is cationic at pH 2.5 because the NH3+ group of cephalexin interacts better with negative functional groups of the basil seed mucilage. Disk Diffusion Anti-Bacterial test showed that the loading of CPX on the Fe3O4@BSM nanocarrier, not only does not have any negative effects on the structure and performance of the drug, but also increases the antibacterial properties of CPX. Furthermore, the in vitro release of Fe3O4@BSM-CPX nanocomposites showed an initial burst release in the first 18 h, followed by a more gradual and sustained release for 120 h.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 113, 1 July 2018, Pages 317-328
نویسندگان
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