کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8328267 | 1540206 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anti-allergic effects of novel sulfated polysaccharide sacran on mouse model of 2,4-Dinitro-1-fluorobenzene-induced atopic dermatitis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
In this study, in order to investigate the potential of the novel polysaccharide sacran from Aphanothece Sacrum for development of atopic dermatitis (AD), we evaluated the potential of pretreatment with topical sacran to prevent the development of hapten (dinitrofluorobenzene: DNFB)-induced AD-like disease in mice. In the AD model mice, sacran markedly ameliorated AD symptoms such as scratching behavior and edema in ear. In addition, sacran significantly increased water content of the stratum corneum which regulates the skin barrier function. Furthermore, sacran significantly inhibited inflammatory cytokine and chemokine mRNA levels in the dermatitis skin as well as the IgE antibody level in serum. Sacran inhibited inflammatory cytokines mRNA production from Jurkat cells derived from human leukemia T cells after stimulation with phorbol 12-myristate 13-acetate/ionomycin. Meanwhile, sacran did not inhibit the proliferation of primary B cells stimulated with lipopolysaccharide. These results suggest that sacran has good anti-allergic effect on AD model mice, probably due to the amelioration of skin barrier function and suppression of immune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 108, March 2018, Pages 112-118
Journal: International Journal of Biological Macromolecules - Volume 108, March 2018, Pages 112-118
نویسندگان
Keiichi Motoyama, Yuki Tanida, Aiko Sakai, Taishi Higashi, Shinichiro Kaneko, Hidetoshi Arima,