کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8328558 1540206 2018 29 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nano-composites chitosan-curcumin synergistically inhibits the oxidative stress induced by toxic metal cadmium
ترجمه فارسی عنوان
کیتوزان-کوروکومین نانو کامپوزیت ها به طور سینرژیک باعث مهار استرس اکسیداتیو ناشی از کادمیوم فلز سمی
کلمات کلیدی
کرکومین، کیتوزان، نانوذرات، استرس اکسیداتیو، ترکیب خون، موش،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
The present study intends to compare the influence of pre-treatment with nanoparticles of curcumin (Cr-NPS), chitosan (Ch-NPS) and nanocomposites chitosan-curcumin (CC-NPS) on cadmium (Cd)-induced oxidative damage in the liver, kidneys, and blood indices in Swiss strain adult male mice. The pretreated mice with Cr-NPS, Ch-NPS, and CC-NPS were exposed to Cd (10 mg/kg) for three weeks. The non-enzymatic Oxidative Stress (OS) indices like lipid peroxides (TBARS), reduced total glutathione (GSH), enzymatic OS indices like catalase (CAT), glutathione S-transferase (GST) and superoxide dismutase (SOD) were estimated together with some blood indices. Cadmium was able to induce a significant increase in TBARS and a significant decrease in GSH, GST, CAT and SOD levels in all the tissues, which were pretreated with nanocomposite. Furthermore, the blood indices like counts of red and white blood cells, platelets, hemoglobin and packed cell volume were also depleted due to Cd exposure but remained unaffected and kept under normal levels in pretreated mice group. The results indicate that Cr-NPS, Ch-NPS, and CC-NPS may act as natural antioxidants and when compared among the three, CC-NPS appears to be the best antioxidant.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 108, March 2018, Pages 591-597
نویسندگان
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