کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8329128 | 1540210 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Honeycomb structural composite polymer network of gelatin and functional cellulose ester for controlled release of omeprazole
ترجمه فارسی عنوان
شبکه پلیمر کامپوزیتی ساختمانی لانه زنبوری ژلاتین و سلولز کارکردی فعال برای کنترل ائوماپورازول
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کلمات کلیدی
ژلاتین، سلولز های میکروکریستالی، پیوند متقابل، امپرازول، انتشار کنترل شده،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
The functionalized cellulose ester MCN was firstly synthesized and used to cross-link gelatin by amidation between âNH2 in gelatin and active ester groups in MCN to form a composite polymer network Gel-MCN, which was confirmed by Van Slyke method, FTIR, XRD and TGA-DTG spectra. The model drug omeprazole was loaded in Gel-MCN composites mainly by electrostatic interaction and hydrogen bonds, which were certified by FTIR, XRD and TGA-DSC. Thermal stability, anti-biodegradability, mechanical property and surface hydrophobicity of the composites with different cross-linking extents and drug loading were systematically investigated. SEM images demonstrated the honeycomb structural cells of cross-linked gelatin networks and this ensured drug entrapment. The drug release mechanism was dominated by a combined effect of diffusion and degradation, and the release rate decreased with cross-linking degree increased. The developed drug delivery system had profound significance in improving pesticide effect and bioavailability of drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 105, Part 3, December 2017, Pages 1644-1653
Journal: International Journal of Biological Macromolecules - Volume 105, Part 3, December 2017, Pages 1644-1653
نویسندگان
Chen Zhuang, Chengmei Shi, Furong Tao, Yuezhi Cui,