کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8329515 1540212 2017 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Degalactosylation of xyloglucans modify their pro-inflammatory properties on murine peritoneal macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Degalactosylation of xyloglucans modify their pro-inflammatory properties on murine peritoneal macrophages
چکیده انگلیسی
Considering the potential applications of partially degalactosylated xyloglucans as a drug delivery vehicle and reconstruction of tissues, the aim of this study was to investigate whether degalactosylated xyloglucans are immunologically active. The effects of the degalactosylated xyloglucan from seeds of Copaifera langsdorffii (XGCd), Hymenaea courbaril (XGJd), and Tamarindus indica (XGTd) on murine peritoneal macrophages in vitro were evaluated. XGCd, XGJd, and XGTd stimulated NO production in a dose-dependent manner reaching ∼280% for XGTd at 50 μg/mL. Regarding cytokines production, XGJd at 50 μg/mL increased IL-1β level by ∼100% and XGCd (10 μg/mL) enhanced IL-6 level by 40%. At 10 μg/mL, XGTd increased TNF- α and IL-1β levels by 104 and 2370%, respectively, as compared to the control group. For IL-6, XGTd enhanced this cytokine production by 80% at all concentrations tested. XGTd exhibited the most intensive effects on the production of pro-inflammatory mediators by peritoneal macrophages. All degalactosylated xyloglucans evaluated showed not to be biologically inert. Thus, this finding is relevant for groups that are investigating the use of degalactosylated xyloglucan from T. indica for drug delivery and reconstruction of tissues. The effects observed could contribute to potentiate the immune system against infections or toxicity to tumor cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 105, Part 1, December 2017, Pages 533-540
نویسندگان
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