کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8329524 | 1540212 | 2017 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thermo-responsive hydroxybutyl chitosan hydrogel as artery intervention embolic agent for hemorrhage control
ترجمه فارسی عنوان
هیدروژل هیدروکسی بیوتیل کیتوزان هیدروکسی بیوتیل ترموپلاستی به عنوان عامل آمبولی مداخلات شریانی برای کنترل خونریزی
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کلمات کلیدی
هیدروکسی بیوتیل کیتوزان، هیدروژل، حرارتی پاسخ، امبولیسازی، خونریزی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
This work targeted to investigate the potential of thermo-responsive hydroxybutyl chitosan (HBC) hydrogel using as an embolic material for occlusion of selective blood vessels. HBC hydrogel was prepared via an etherification reaction between chitosan (CS) and 1, 2-butene oxide. The hydroxybutyl groups were introduced into CS backbone, which endowed HBC hydrogel with properties of porous structure, favorable hydrophilia and rapid sol-gel interconvertibility. The gelation temperatures and gelation time respectively decreased from 30.7 °C to 11.5 °C and 79.60 ± 3.19 s to 7.70 ± 1.42 s at 37 °C, with HBC solutions viscoelasticity increased from 3.0% to 7.0%. HBC hydrogel exhibited noncytotoxic to mouse embryo fibroblasts (MEFs) and excellent hemocompatibility with red blood cells (RBCs). After injection HBC solution into rat renal arteries, HBC solution transformed into hydrogel and attached onto blood vessel inner wall tightly, giving immediate blood vessels embolization. Meanwhile, RBCs could aggregate around HBC hydrogel to form moderate coagulation, which was beneficial to avoid hydrogel migration with blood flow. Above results suggested that HBC hydrogel could be applied as a promising embolic agent for hemorrage in the interventional vascular embolization field.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 105, Part 1, December 2017, Pages 566-574
Journal: International Journal of Biological Macromolecules - Volume 105, Part 1, December 2017, Pages 566-574
نویسندگان
Guohui Sun, Chao Feng, Changqing Jiang, Tingting Zhang, Zixian Bao, Yajun Zuo, Ming Kong, Xiaojie Cheng, Ya Liu, Xiguang Chen,