کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8329668 | 1540228 | 2016 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Physicochemical investigations of biogenic chitosan-silver nanocomposite as antimicrobial and anticancer agent
ترجمه فارسی عنوان
بررسی فیزیکوشیمیایی نانوکامپوزیت نقره کیتوزان بیوژنیک به عنوان عامل ضد میکروبی و ضد سرطان
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کلمات کلیدی
کیتوزان، نانوکامپوزیت، ضد باکتری، ضد سرطان،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Chitosan (CS), a seaweed polysaccharide is a natural macromolecule which is widely being used in medical applications because of its distinctive antimicrobial and anticancer properties. Silver, a noble metal, is also receiving wide attention for its potential usage in antimicrobial and anticancer therapeutics. In this study, an effective way of reduction of silver using chitosan at varying reaction temperatures and an optimised concentration of silver were performed. The optical, structural, spectral, morphological and elemental studies of the biosynthesized chitosan-silver (CS-Ag) nanocomposites were characterized by several techniques. The synthesized CS-Ag nanocomposites exhibit particle size around 20 nm and were further exploited for potent biological applications in nanomedicine due to their nanometric sizes and biocompatibility of chitosan. The antimicrobial activity of the biosynthesized CS-Ag nanocomposites exhibits zone of inhibition ranged between 09.666 ± 0.577 and 19.000 ± 1.000 (mm). The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were from 8 to 128 μg mLâ1 and 16 to 256 μg mLâ1 respectively, with the highest antimicrobial activity shown against Gram-negative Salmonella sp. The synergistic effect of chitosan and silver as a composite in nanometric size revealed significant IC50 value of 29.35 μg mLâ1 and a maximum of 95.56% inhibition at 100 μg mLâ1 against A549 lung cancer cell line, resulting in potent anticancer effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 92, November 2016, Pages 77-87
Journal: International Journal of Biological Macromolecules - Volume 92, November 2016, Pages 77-87
نویسندگان
Nithya Arjunan, Henry Linda Jeeva Kumari, Chandra Mohan Singaravelu, Ruckmani Kandasamy, Jothivenkatachalam Kandasamy,